Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | BCDIN3D | Q7Z5W3 | 15/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943301 | 0.86 | TP53 (0.66) | TP53PDE2ABCDIN3DHTR2C | |
| SCHEMBL13944193 | 0.85 | TP53 (0.65) | TP53SHMT2PDE2ABCDIN3DHTR2C | |
| SCHEMBL13947360 | 0.83 | TP53 (0.62) | TP53PDE2ABCDIN3DHTR2C | |
| SCHEMBL13943257 | 0.82 | TP53 (0.66) | TP53BCDIN3DHTR2C | |
| SCHEMBL13942972 | 0.82 | HTR2C (0.65) | SHMT2PDE2ABCDIN3DHTR2C | |
| SCHEMBL13946817 | 0.80 | HTR2C (0.69) | TP53SHMT2BCDIN3DHTR2C | |
| SCHEMBL13943748 | 0.80 | TP53 (0.61) | TP53SHMT2PDE2ABCDIN3DHTR2C | |
| SCHEMBL13943723 | 0.78 | SHMT2 (0.66) | SHMT2BCDIN3D | |
| SCHEMBL13943302 | 0.77 | SHMT2 (0.68) | TP53SHMT2BCDIN3DHTR2C | |
| SCHEMBL13944187 | 0.77 | TP53 (0.80) | TP53PDE2ABCDIN3DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |