Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | BCDIN3D | Q7Z5W3 | 15/20 | 0.56 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943258 | 0.83 | BCDIN3D (0.59) | HTR2CBCDIN3DSHMT2PDE2A | |
| SCHEMBL13942964 | 0.83 | HTR2C (0.67) | TP53HTR2CBCDIN3DSHMT2 | |
| SCHEMBL13943690 | 0.82 | HTR2C (0.69) | TP53HTR2CBCDIN3DSHMT2 | |
| SCHEMBL13943301 | 0.81 | TP53 (0.66) | TP53HTR2CBCDIN3DPDE2A | |
| SCHEMBL13944370 | 0.80 | PDE2A (0.65) | TP53HTR2CBCDIN3DSHMT2PDE2A | |
| SCHEMBL13087520 | 0.80 | TP53 (0.46) | TP53HTR2CBCDIN3DPDE2A | |
| SCHEMBL13947367 | 0.80 | TP53 (0.65) | TP53HTR2CBCDIN3DSHMT2PDE2A | |
| SCHEMBL13944193 | 0.80 | TP53 (0.65) | TP53HTR2CBCDIN3DSHMT2PDE2A | |
| SCHEMBL13947360 | 0.78 | TP53 (0.62) | TP53HTR2CBCDIN3DPDE2A | |
| SCHEMBL13943321 | 0.78 | TP53 (0.65) | TP53HTR2CBCDIN3DPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |