Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088259 | 0.85 | ALDH1A1 (0.64) | ALDH1A1HTTMAPTKDM4EPOLB | |
| SCHEMBL4207082 | 0.82 | PTGS2 (0.51) | CREBBPALDH1A1HTTMAPTKDM4E | |
| SCHEMBL4207096 | 0.82 | PTGS2 (0.51) | CREBBPALDH1A1HTTMAPTKDM4E | |
| SCHEMBL9192282 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HTTMAPTKDM4ETP53 | |
| SCHEMBL13947393 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HTTMAPTMTNR1AMTNR1B | |
| SCHEMBL19275945 | 0.78 | MEN1 (0.56) | CREBBPALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL6354556 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HTTMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL11638326 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HTTMAPTKDM4ETP53 | |
| SCHEMBL16385719 | 0.76 | ALDH1A1 (0.62) | ALDH1A1HTTMAPTSMN1; SMN2POLB | |
| SCHEMBL13947395 | 0.76 | ALDH1A1 (0.62) | ALDH1A1HTTMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482488-B2 | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-01-27 | — | — | US | disclosed |