Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 12/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL6036229 | 0.98 | GRM4 (0.40) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL29590771 | 0.96 | GRM4 (0.38) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL6476656 | 0.96 | GRM4 (0.38) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL5944129 | 0.87 | — | — | |
| Water SCHEMBL6036672 | 0.84 | GRM4 (0.36) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL31174052 | 0.81 | PLK1 (0.35) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL6333956 | 0.75 | CCNA2 (0.41) | GRM4CCNA2CDK2CCNA1 | |
| SCHEMBL20919789 | 0.75 | CDC7 (0.45) | GRM4PKN1PKN2PLK1CSNK2A1 | |
| SCHEMBL13513362 | 0.71 | GRM4 (0.42) | GRM4KCNH2CCNA2CDK2CCNA1 | |
| SCHEMBL8025740 | 0.69 | GRM4 (0.38) | GRM4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069325-A2 | ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES | Serenex, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008024977-A2 | ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| EP-0590558-B1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | THOMAE GMBH DR K (DE) | 1995-12-06 | — | — | EP | claimed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | claimed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | claimed |
| JP-6211802-A | — | — | None | — | — | JP | disclosed |
| US-20250326749-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250325552-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2025-10-23 | — | — | US | disclosed |
| EP-4536655-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119677730-A | Compounds, compositions, and methods of use thereof | 希安纳医疗公司 | 2025-03-21 | — | — | CN | disclosed |
| EP-4423069-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| US-12071411-B2 | Inhibitors of HIF-2α and methods of use thereof | ARCUS BIOSCIENCES, INC. (US) | 2024-08-27 | — | — | US | disclosed |
| EP-0590558-B1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | THOMAE GMBH DR K (DE) | 1995-12-06 | — | — | EP | disclosed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |
| JP-H06211802-A | 1,5,6,7-TETRAHYDRO-4H-INDAZOL-4-ONES, ANALGESIC, ANTIPYRETIC AND ANTIPHLOGISTIC PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND THEIR PREPARATION | DR KARL THOMAE GMBH | 1994-08-02 | — | — | JP | disclosed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250325552-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLK, POLH | GRM4 4270/4885PKN1 1870/4885PKN2 2321/4885 |
| US-20250326749-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | CFTR, SLC26A4, PKD2 | GRM4 4662/4885PKN1 3266/4885PKN2 3198/4885 |
| US-12071411-B2 | Inhibitors of HIF-2α and methods of use thereof | HIF1AN, HIF1A, EGLN2 | GRM4 4484/4885PKN1 1258/4885PKN2 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.