Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.44 |
| ▸ | CDK2AP1 | O14519 | 7/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706488 | 0.91 | CHEK1 (0.56) | CHEK1CDK2AP1FAAHHTR7USP30 | |
| SCHEMBL5556375 | 0.88 | CHEK1 (0.54) | CHEK1CDK2AP1USP30 | |
| SCHEMBL5554768 | 0.85 | CHEK1 (0.51) | CHEK1CDK2AP1 | |
| SCHEMBL4702699 | 0.85 | CHEK1 (0.54) | CHEK1CDK2AP1FAAHKDM4E | |
| SCHEMBL4211957 | 0.84 | CHEK1 (0.54) | CHEK1CDK2AP1FAAHUSP30 | |
| Trifluoroacetic Acid SCHEMBL4223931 | 0.83 | CHEK1 (0.51) | CHEK1CDK2AP1FAAHUSP30 | |
| SCHEMBL4210048 | 0.83 | CHEK1 (0.44) | CHEK1CDK2AP1KDM4E | |
| SCHEMBL1562936 | 0.82 | USP30 (0.55) | CHEK1CDK2AP1USP30 | |
| SCHEMBL1563863 | 0.80 | USP30 (0.53) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4703475 | 0.79 | CHEK1 (0.53) | CHEK1CDK2AP1FAAHHTR7USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | TPMT, ABCG2, TYMP | CHEK1 297/4885CDK2AP1 2722/4885FAAH 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.