Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.54 |
| ▸ | CDK2AP1 | O14519 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706488 | 0.94 | CHEK1 (0.56) | CHEK1CDK2AP1FAAHSYK | |
| SCHEMBL4213212 | 0.92 | CHEK1 (0.52) | CHEK1CDK2AP1BTK | |
| SCHEMBL5815671 | 0.88 | CHEK1 (0.53) | CHEK1CDK2AP1JAK3BTKHRH2 | |
| SCHEMBL4206504 | 0.88 | CHEK1 (0.60) | CHEK1CDK2AP1JAK3BTK | |
| SCHEMBL4211957 | 0.87 | CHEK1 (0.54) | CHEK1CDK2AP1BTKFAAH | |
| SCHEMBL4706425 | 0.87 | CHEK1 (0.51) | CHEK1CDK2AP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4210048 | 0.86 | CHEK1 (0.44) | CHEK1CDK2AP1KDM4ERAB9ACHRNB2 | |
| SCHEMBL4208380 | 0.86 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL4216335 | 0.86 | CHEK1 (0.72) | CHEK1CDK2AP1 | |
| SCHEMBL4706485 | 0.86 | CHEK1 (0.72) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |