Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.56 |
| ▸ | CDK2AP1 | O14519 | 6/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702699 | 0.94 | CHEK1 (0.54) | CHEK1CDK2AP1FAAHSYK | |
| SCHEMBL4211957 | 0.93 | CHEK1 (0.54) | CHEK1CDK2AP1FAAHUSP30 | |
| SCHEMBL13951997 | 0.91 | CHEK1 (0.44) | CHEK1CDK2AP1FAAHHTR7USP30 | |
| Trifluoroacetic Acid SCHEMBL4223931 | 0.91 | CHEK1 (0.51) | CHEK1CDK2AP1FAAHUSP30 | |
| SCHEMBL4703475 | 0.88 | CHEK1 (0.53) | CHEK1CDK2AP1FAAHHTR7SYK | |
| SCHEMBL4213212 | 0.88 | CHEK1 (0.52) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4705891 | 0.87 | CHEK1 (0.73) | CHEK1CDK2AP1 | |
| SCHEMBL4220643 | 0.86 | CHEK1 (0.75) | CHEK1CDK2AP1 | |
| SCHEMBL5556375 | 0.86 | CHEK1 (0.54) | CHEK1CDK2AP1USP30 | |
| SCHEMBL4224436 | 0.86 | CHEK1 (0.64) | CHEK1CDK2AP1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |