Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 16/20 | 0.55 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 8/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14530730 | 0.83 | PTK6 (0.54) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL8241176 | 0.83 | AURKA (0.58) | PTK6MAPKAPK5AURKBAURKATTK | |
| SCHEMBL14537083 | 0.80 | PTK6 (0.56) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL14538620 | 0.80 | PTK6 (0.59) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL14530402 | 0.79 | MAPKAPK5 (0.58) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL14530726 | 0.78 | PTK6 (0.56) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL14536960 | 0.78 | MAPKAPK5 (0.62) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL30138985 | 0.78 | MAPKAPK5 (0.62) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL1674071 | 0.77 | MAPKAPK5 (0.70) | PTK6MAPKAPK5AURKBAURKALCK | |
| SCHEMBL14536802 | 0.77 | PTK6 (0.54) | PTK6MAPKAPK5AURKBAURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |