Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | TTK | P33981 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537009 | 0.92 | FLT3 (0.46) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL14529893 | 0.89 | ADORA3 (0.48) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL8240563 | 0.88 | AURKA (0.53) | FLT3TTKAURKAAURKB | |
| SCHEMBL14530017 | 0.87 | FLT3 (0.56) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL8240135 | 0.79 | AURKA (0.58) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL13955023 | 0.79 | TTK (0.41) | FLT3TTKAURKAAURKB | |
| SCHEMBL14537008 | 0.79 | AURKA (0.46) | FLT3TTKAURKAAURKB | |
| SCHEMBL8246210 | 0.76 | AURKA (0.55) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL8241005 | 0.75 | AURKA (0.64) | FLT3TTKAURKAAURKBADORA3 | |
| SCHEMBL14536949 | 0.75 | TTK (0.46) | FLT3TTKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |