Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | TTK | P33981 | 11/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536949 | 0.84 | TTK (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14530182 | 0.82 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14538587 | 0.80 | AURKA (0.44) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536731 | 0.80 | AURKA (0.49) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14529894 | 0.80 | AURKA (0.42) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537007 | 0.80 | AURKA (0.48) | AURKAAURKBTTK | |
| SCHEMBL14536794 | 0.79 | AURKA (0.48) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954584 | 0.79 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954859 | 0.79 | FLT3 (0.47) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14530017 | 0.79 | FLT3 (0.56) | AURKAAURKBTTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |