Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254328 | 0.88 | HSD17B10 (0.46) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL2801616 | 0.86 | CYP2A13 (0.51) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL110824 | 0.85 | CYP2A13 (0.58) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL428922 | 0.85 | CYP2A13 (0.50) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL12909233 | 0.83 | CYP2A13 (0.51) | HSD17B10CYP2C9ALOX15CYP2A13KDM4E | |
| SCHEMBL2800997 | 0.81 | PDE3B (0.45) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL424879 | 0.81 | TBK1 (0.42) | HSD17B10CYP2C9ALOX15CYP2A13ROCK1 | |
| SCHEMBL18580216 | 0.81 | L3MBTL1 (0.42) | ROCK1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL146568 | 0.78 | HRH3 (0.56) | ALDH1A1LMNAMAPTLPLLIPG | |
| SCHEMBL13957871 | 0.77 | POLB (0.44) | HSD17B10ALOX15KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010488-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS | NOVARTIS AG (CH) | 2009-01-22 | — | — | WO | disclosed |