Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL235307 | 0.85 | AOC3 (0.36) | BACE1RENCTSDBACE2 | |
| SCHEMBL3863909 | 0.77 | CFD (0.37) | BACE1RENCTSDBACE2HTR2A | |
| SCHEMBL233814 | 0.72 | BACE1 (0.37) | BACE1RENCTSDBACE2 | |
| SCHEMBL234993 | 0.71 | TAAR1 (0.47) | — | |
| SCHEMBL236490 | 0.71 | TAAR1 (0.41) | — | |
| SCHEMBL19291675 | 0.71 | AOC3 (0.50) | — | |
| SCHEMBL17755174 | 0.71 | AOC3 (0.50) | — | |
| SCHEMBL11467211 | 0.71 | ADRB1 (0.53) | HTR2AHRH1 | |
| SCHEMBL235313 | 0.70 | HTR2C (0.34) | — | |
| SCHEMBL232888 | 0.69 | HTR2A (0.40) | HTR2AASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |