Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.46 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961448 | 0.90 | GSK3B (0.50) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961709 | 0.88 | GSK3B (0.46) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961465 | 0.87 | GSK3A (0.48) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961466 | 0.87 | PIM2 (0.47) | GSK3BGSK3APIM2MAPT | |
| SCHEMBL13961453 | 0.87 | CHEK1 (0.56) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961713 | 0.87 | PIM2 (0.48) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961456 | 0.86 | GSK3B (0.47) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961468 | 0.85 | CHEK1 (0.57) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13027847 | 0.85 | CHEK1 (0.53) | GSK3BGSK3ACHEK1ATRPIM3 | |
| SCHEMBL13961609 | 0.85 | GSK3B (0.46) | GSK3BGSK3ACHEK1ATRPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014637-A2 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-01-29 | — | — | WO | disclosed |