Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961448 | 0.90 | GSK3B (0.50) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13961465 | 0.89 | GSK3A (0.48) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13027817 | 0.87 | CHEK1 (0.51) | PIM2PIM3GSK3BGSK3ACHEK1 | |
| SCHEMBL13961709 | 0.87 | GSK3B (0.46) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13961607 | 0.87 | GSK3B (0.46) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13028279 | 0.87 | PIM2 (0.48) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13961456 | 0.86 | GSK3B (0.47) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13068385 | 0.85 | PIM2 (0.49) | PIM2PIM3GSK3BGSK3APRKCA | |
| SCHEMBL13961466 | 0.85 | PIM2 (0.47) | PIM2GSK3BGSK3AMAPT | |
| SCHEMBL13961453 | 0.85 | CHEK1 (0.56) | PIM2PIM3GSK3BGSK3APRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014637-A2 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2009-01-29 | — | — | WO | disclosed |