Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490611 | 0.85 | ROCK2 (0.53) | HPGDCYP3A4GSK3AGSK3BCCNB2 | |
| SCHEMBL4499726 | 0.81 | ROCK2 (0.42) | HPGDCYP3A4ROCK2 | |
| SCHEMBL14563447 | 0.76 | ALDH1A1 (0.47) | HPGDCYP3A4GSK3AGSK3BCCNB2 | |
| SCHEMBL4050365 | 0.76 | HPGD (0.43) | HPGDCYP3A4MAPTPDE1BKMT2A | |
| SCHEMBL4050872 | 0.76 | HPGD (0.43) | HPGDCYP3A4MAPTPDE1BKMT2A | |
| SCHEMBL4051429 | 0.76 | HPGD (0.43) | HPGDCYP3A4MAPTPDE1BKMT2A | |
| SCHEMBL14408874 | 0.75 | KDM4E (0.47) | HPGDCYP3A4GSK3AGSK3BMAPT | |
| SCHEMBL4367588 | 0.74 | TLR7 (0.46) | HPGDMAPTKMT2ABRD4TDP1 | |
| SCHEMBL13956768 | 0.74 | TLR7 (0.46) | HPGDCYP3A4MAPTKMT2ATDP1 | |
| SCHEMBL4365755 | 0.74 | TLR7 (0.46) | HPGDMAPTKMT2ABRD4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476743-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-7476743-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2009-01-13 | — | — | US | disclosed |