Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 15/20 | 0.48 |
| ▸ | KDR | P35968 | 14/20 | 0.48 |
| ▸ | IGF1R | P08069 | 13/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396735 | 0.93 | PTK2B (0.54) | PTK2BMETKDRPDGFRAKIT | |
| SCHEMBL1396795 | 0.91 | PTK2B (0.54) | PTK2BMETKDRIGF1RAURKA | |
| SCHEMBL1396757 | 0.83 | PTK2B (0.46) | PTK2BMETKDRPDGFRAKIT | |
| SCHEMBL1396842 | 0.82 | PTK2B (0.52) | PTK2BMETKDRPDGFRA | |
| SCHEMBL1396685 | 0.80 | PTK2B (0.55) | PTK2BMETKDRPDGFRAKIT | |
| SCHEMBL1396736 | 0.78 | PTK2B (0.53) | PTK2BMETKDRPDGFRAKIT | |
| SCHEMBL1396864 | 0.75 | PTK2B (0.57) | PTK2BMETKDRIGF1RAURKA | |
| SCHEMBL1396738 | 0.73 | MET (0.48) | PTK2BMETKDRIGF1RPDGFRA | |
| SCHEMBL1396822 | 0.71 | MET (0.49) | PTK2BMETKDRPDGFRAKIT | |
| SCHEMBL1396814 | 0.71 | PTK2B (0.53) | PTK2BMETKDRIGF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | claimed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | claimed |
| EP-2288383-A1 | COMBINATIONS VEGF(R) INHIBITORS AND HEPATOCYTE GROWTH FACTOR (C-MET) INHIBITORS FOR THE TREATMENT OF CANCER | Amgen, Inc (US) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009140549-A1 | COMBINATIONS VEGF(R) INHIBITORS AND HEPATOCYTE GROWTH FACTOR (C-MET) INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2009-11-19 | — | — | WO | disclosed |
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |