Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13963460 | 0.89 | SMN1; SMN2 (0.47) | ATMELANECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13963457 | 0.81 | ROCK2 (0.51) | ROCK2CTSKSMN1; SMN2 | |
| SCHEMBL14416026 | 0.78 | ATM (0.47) | ATMELANECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13973860 | 0.77 | ATM (0.46) | ATMELANECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4497212 | 0.75 | ROCK2 (0.46) | ROCK2CTSKSMN1; SMN2 | |
| SCHEMBL5110580 | 0.74 | AAK1 (0.47) | ATMELANECYP3A4CCR1 | |
| SCHEMBL8295707 | 0.72 | ATM (0.57) | ATMELANECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7412044 | 0.72 | MAPT (0.49) | ATMELANECTSKPRTN3CTSB | |
| SCHEMBL14614699 | 0.69 | ATM (0.44) | ATMELANECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17688547 | 0.68 | ATM (0.61) | ATMELANECTSKPRTN3CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476743-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2009-01-13 | — | — | US | disclosed |