Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | RGS4 | P49798 | 1/20 | 0.38 |
| ▸ | RGS8 | P57771 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497212 | 0.83 | ROCK2 (0.46) | ROCK2LMNASMN1; SMN2TP53CTSK | |
| SCHEMBL4490611 | 0.82 | ROCK2 (0.53) | ROCK2LMNAHPGDCCNB2CDK1 | |
| SCHEMBL13973864 | 0.81 | ROCK2 (0.48) | ROCK2SMN1; SMN2CTSK | |
| SCHEMBL13963464 | 0.75 | ROCK2 (0.43) | ROCK2MAPT | |
| SCHEMBL14408873 | 0.73 | KDM4E (0.44) | LMNASMN1; SMN2HPGDCCNB2CDK1 | |
| SCHEMBL13963463 | 0.69 | HPGD (0.43) | ROCK2HPGDCCNB2CDK1CCNB1 | |
| SCHEMBL28976779 | 0.69 | ROCK2 (0.68) | ROCK2LMNACCNB2CDK1CCNB1 | |
| SCHEMBL3587556 | 0.69 | NPC1 (0.56) | ROCK2LMNASMN1; SMN2CTSKRGS4 | |
| SCHEMBL4499726 | 0.68 | ROCK2 (0.42) | ROCK2HPGD | |
| SCHEMBL13963465 | 0.67 | F11 (0.40) | LMNAHPGDTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476743-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2009-01-13 | — | — | US | disclosed |