Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13974434 | 0.86 | KDM4E (0.49) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL13974260 | 0.81 | DGAT1 (0.54) | L3MBTL1HTR3A | |
| SCHEMBL3137101 | 0.77 | KDM4E (0.53) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL2385606 | 0.77 | HRH4 (0.58) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL12412565 | 0.75 | HRH4 (0.56) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL2384691 | 0.74 | HTR6 (0.66) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL2388259 | 0.74 | TLR9 (0.50) | KDM4ERAD52UBE2NL3MBTL1HRH4 | |
| SCHEMBL15317749 | 0.74 | ABL1 (0.51) | LRRK2ABL1 | |
| SCHEMBL18436092 | 0.74 | OGA (0.54) | KDM4EL3MBTL1HRH3ALDH1A1CYP1A2 | |
| SCHEMBL15344219 | 0.73 | RAD52 (0.55) | KDM4ERAD52UBE2NL3MBTL1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158784-A2 | MODULATORS OF THE NUCLEAR HORMONE RECEPTOR ROR | KAMENECKA THEODORE MARK (US) | 2012-11-22 | — | — | WO | disclosed |