Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12790339 | 0.93 | CHEK2 (0.53) | ATMMAPTSMN1; SMN2TP53MMP2 | |
| SCHEMBL12790323 | 0.91 | ATM (0.52) | ATMMAPTSMN1; SMN2TP53MMP2 | |
| SCHEMBL13974300 | 0.88 | HDAC6 (0.45) | ATMMAPTSMN1; SMN2TP53HDAC6 | |
| SCHEMBL12790045 | 0.87 | ATM (0.55) | ATMMAPTSMN1; SMN2MMP2MMP9 | |
| SCHEMBL13974398 | 0.85 | HDAC6 (0.46) | ATMMAPTSMN1; SMN2TP53HDAC6 | |
| SCHEMBL8770360 | 0.84 | ATM (0.57) | ATMMAPTSMN1; SMN2TP53MMP2 | |
| SCHEMBL8770285 | 0.83 | ATM (0.50) | ATMMAPTSMN1; SMN2TP53MMP2 | |
| SCHEMBL12790090 | 0.82 | ATM (0.43) | ATMMAPTSMN1; SMN2TP53MMP2 | |
| SCHEMBL12790054 | 0.82 | MAPT (0.53) | ATMMAPTSMN1; SMN2MMP2MMP9 | |
| SCHEMBL12791510 | 0.82 | MMP2 (0.56) | ATMMAPTSMN1; SMN2MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295904-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295904-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | MPL, CSF3R, HGF | ATM 2698/4885MAPT 4411/4885SMN1; SMN2 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.