Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.58 |
| ▸ | DRD1 | P21728 | 8/20 | 0.58 |
| ▸ | DRD4 | P21917 | 8/20 | 0.58 |
| ▸ | DRD5 | P21918 | 8/20 | 0.58 |
| ▸ | DRD2 | P14416 | 8/20 | 0.58 |
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13975497 | 0.95 | DRD3 (0.59) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL21148627 | 0.85 | DRD3 (0.71) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL13974994 | 0.81 | DRD3 (0.61) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL21936084 | 0.80 | NTRK1 (0.43) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL13858452 | 0.80 | NTRK1 (0.43) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL28225266 | 0.78 | DRD2 (0.61) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL25946287 | 0.78 | DRD2 (0.69) | DRD3DRD1DRD4DRD5DRD2 | |
| SCHEMBL1823938 | 0.76 | SLC6A2 (0.41) | DRD3DRD2HTR1A | |
| SCHEMBL8571166 | 0.76 | DRD2 (0.59) | DRD3DRD1DRD5DRD2HTR1A | |
| SCHEMBL13698261 | 0.75 | DRD3 (0.61) | DRD3DRD1DRD4DRD5DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158413-A2 | PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |