Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 9/20 | 0.71 |
| ▸ | DRD2 | P14416 | 9/20 | 0.71 |
| ▸ | DRD1 | P21728 | 8/20 | 0.71 |
| ▸ | DRD4 | P21917 | 8/20 | 0.71 |
| ▸ | DRD5 | P21918 | 8/20 | 0.71 |
| ▸ | HTR1A | P08908 | 7/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28225266 | 0.93 | DRD2 (0.61) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL21148630 | 0.85 | DRD3 (0.54) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL13975498 | 0.85 | DRD3 (0.58) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL21147738 | 0.82 | DRD2 (0.51) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL30010653 | 0.82 | DRD2 (0.51) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL13974997 | 0.82 | DRD2 (0.51) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL25946287 | 0.82 | DRD2 (0.69) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL13974994 | 0.82 | DRD3 (0.61) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL13975497 | 0.81 | DRD3 (0.59) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL7500515 | 0.80 | DRD2 (0.47) | DRD3DRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154959-B1 | 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | ARRAY BIOPHARMA INC (US) | 2019-07-10 | — | — | EP | disclosed |