Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.42 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13967496 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL29011073 | 0.80 | MAPT (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL30387174 | 0.80 | MAPT (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12927734 | 0.79 | DYRK1A (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12927788 | 0.79 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL30385875 | 0.78 | KDM4E (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL28914531 | 0.78 | KDM4E (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12850681 | 0.78 | LMNA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12928187 | 0.76 | PIK3CG (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT | |
| SCHEMBL12927783 | 0.73 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120294930-A1 | COMBINATION OF KINASE INHIBITORS AND USES THEREOF | INTELLIKINE LLC (US) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120294930-A1 | COMBINATION OF KINASE INHIBITORS AND USES THEREOF | MTOR, AKT2, MTMR1 | PIK3CA 6/4885PIK3CD 24/4885PIK3CB 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.