Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21658656 | 0.84 | NPC1 (0.48) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL13978226 | 0.81 | KMT2A (0.45) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL13977940 | 0.78 | NOS1 (0.43) | LMNAKMT2AMAPTGAAPOLB | |
| SCHEMBL13977929 | 0.76 | F7 (0.47) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL23183202 | 0.72 | NAPRT (0.38) | NPC1KMT2AGAAMEN1KDM4E | |
| SCHEMBL282987 | 0.69 | KDM1A (0.53) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL834376 | 0.69 | PLG (0.50) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL641911 | 0.69 | KDM1A (0.53) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL282989 | 0.69 | KDM1A (0.53) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL24170745 | 0.67 | NPC1 (0.46) | NPC1RAB9ALMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012156920-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2012-11-22 | — | — | WO | disclosed |