Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.66 |
| ▸ | KDM4A | O75164 | 2/20 | 0.66 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
| ▸ | KDM6A | O15550 | 1/20 | 0.57 |
| ▸ | TET3 | O43151 | 1/20 | 0.57 |
| ▸ | KDM4B | O94953 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.57 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.57 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.57 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18541841 | 0.87 | PSMD14 (0.77) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL18539683 | 0.87 | PSMD14 (0.77) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL15703105 | 0.87 | PSMD14 (0.77) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL13977968 | 0.83 | PSMD14 (0.71) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL69905 | 0.82 | KDM4E (0.74) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL28105356 | 0.82 | PSMD14 (0.69) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL298623 | 0.79 | KDM4E (1.00) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL18541842 | 0.79 | PSMD14 (0.64) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 | |
| SCHEMBL13978047 | 0.79 | PSMD14 (0.71) | PSMD14L3MBTL1EGLN1LMNAHPGD | |
| SCHEMBL23754362 | 0.78 | KDM4E (0.68) | PSMD14KDM4EL3MBTL1KDM4AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2014066506-A2 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-05-01 | — | — | WO | disclosed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | USP24, USP36, USP39 | PSMD14 7/4885KDM4E 2753/4885L3MBTL1 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.