Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 12/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399873 | 1.00 | SERPINE1 (0.57) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14399854 | 0.91 | SERPINE1 (0.47) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14399876 | 0.89 | SERPINE1 (0.55) | SERPINE1HRH3MAPT | |
| SCHEMBL13979781 | 0.88 | SERPINE1 (0.49) | SERPINE1HRH3MEN1MAPTKMT2A | |
| SCHEMBL13979764 | 0.88 | SERPINE1 (0.49) | SERPINE1HRH3MEN1MAPTKMT2A | |
| SCHEMBL13979780 | 0.88 | SERPINE1 (0.49) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL14400073 | 0.88 | SERPINE1 (0.47) | SERPINE1HRH3CYP2D6MEN1MAPT | |
| SCHEMBL14400071 | 0.88 | SERPINE1 (0.45) | SERPINE1HRH3CYP2D6MEN1KMT2A | |
| SCHEMBL6380172 | 0.86 | SERPINE1 (0.74) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6380170 | 0.86 | SERPINE1 (0.74) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282609-B1 | PIPERAZINEDIONE COMPOUNDS | ANGIORX CORP (TW) | 2008-12-17 | — | — | EP | disclosed |