Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 8/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 8/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399876 | 0.90 | SERPINE1 (0.55) | SERPINE1HRH3MAPT | |
| SCHEMBL14399854 | 0.89 | SERPINE1 (0.47) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL13979781 | 0.89 | SERPINE1 (0.49) | SERPINE1HRH3PIM1PIM2MAPT | |
| SCHEMBL13979764 | 0.89 | SERPINE1 (0.49) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL14399873 | 0.88 | SERPINE1 (0.57) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL13979779 | 0.88 | SERPINE1 (0.57) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL14400074 | 0.84 | SERPINE1 (0.45) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL30712993 | 0.84 | SERPINE1 (0.42) | SERPINE1HRH3MAPTKMT2A | |
| SCHEMBL14400068 | 0.84 | SERPINE1 (0.45) | SERPINE1HRH3MAPT | |
| SCHEMBL14399877 | 0.82 | SERPINE1 (0.42) | SERPINE1HRH3MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282609-B1 | PIPERAZINEDIONE COMPOUNDS | ANGIORX CORP (TW) | 2008-12-17 | — | — | EP | disclosed |
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |