Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1397993 | 0.86 | HRH3 (0.56) | HRH3GPR119KMT2ACHEK2 | |
| SCHEMBL15642824 | 0.85 | RAB9A (0.51) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3249504 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3249499 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL18331897 | 0.83 | PDE4D (0.45) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL14205186 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1397942 | 0.82 | HRH3 (0.68) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3248849 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1397970 | 0.80 | HRH3 (0.74) | HRH3GPR119MEN1KMT2A | |
| SCHEMBL1375168 | 0.80 | GPR119 (0.61) | GPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957479-B1 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |
| US-7745479-B2 | 1,5-substituted indol-2-yl amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-06-29 | — | — | US | disclosed |
| EP-1957479-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007062999-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123515-A1 | 1,5-Substituted indol-2-yl amide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123515-A1 | 1,5-Substituted indol-2-yl amide derivatives | HRH4, HRH3, HRH2 | KDM4E 810/4885ALDH1A1 509/4885HPGD 1057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.