Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.49 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932001 | 0.85 | ESR1 (0.56) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3925355 | 0.76 | NPC1 (0.55) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL13980461 | 0.76 | NPC1 (0.55) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3933862 | 0.76 | CSNK2A2 (0.57) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3922827 | 0.76 | NPC1 (0.55) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3934054 | 0.73 | MAPT (0.57) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL1740975 | 0.70 | SIRT1 (0.69) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL311405 | 0.68 | MAPT (1.00) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL31741263 | 0.68 | MAPT (1.00) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 | |
| SCHEMBL29941531 | 0.66 | ESR1 (1.00) | NPC1CYP3A4HPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458700-B1 | SUBSTITUTED 2-PHENYL BENZOFURANS AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-12-03 | — | — | EP | disclosed |