Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 9/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982482 | 0.90 | AKR1B1 (0.33) | PTGESAKR1B1LMNAEPHX2ROCK2 | |
| SCHEMBL13982082 | 0.90 | LMNA (0.36) | PTGESAKR1B1LMNAEPHX2ROCK2 | |
| SCHEMBL13982245 | 0.89 | LMNA (0.34) | PTGESAKR1B1LMNAEPHX2ROCK2 | |
| SCHEMBL3034302 | 0.88 | CYP3A4 (0.41) | PTGESLMNAEPHX2KLKB1 | |
| SCHEMBL13982246 | 0.86 | PTGES (0.34) | PTGESAKR1B1 | |
| SCHEMBL13982427 | 0.85 | PTGES (0.35) | PTGESSCN9A | |
| SCHEMBL13982214 | 0.85 | LMNA (0.36) | PTGESAKR1B1LMNAEPHX2KLKB1 | |
| SCHEMBL13982258 | 0.85 | PTGES (0.37) | PTGESAKR1B1LMNAEPHX2KLKB1 | |
| SCHEMBL13982267 | 0.83 | AKR1B1 (0.33) | PTGESAKR1B1LMNAEPHX2ROCK2 | |
| SCHEMBL13982338 | 0.82 | LMNA (0.36) | PTGESAKR1B1LMNAEPHX2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |