Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983278 | 0.98 | DHODH (0.34) | FFAR1FFAR4IRAK4SYKNR3C1 | |
| SCHEMBL13983283 | 0.95 | JAK2 (0.33) | DHODHJAK2JAK3ROCK2OPRL1 | |
| SCHEMBL13983256 | 0.89 | P2RX7 (0.32) | P2RX7 | |
| SCHEMBL13983252 | 0.89 | TRPV1 (0.37) | FFAR1FFAR4NR3C1JAK2JAK3 | |
| SCHEMBL13983263 | 0.87 | PIK3CA (0.32) | DHODHCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13983254 | 0.86 | TRPV1 (0.37) | JAK2JAK3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13983285 | 0.84 | — | — | |
| SCHEMBL13983267 | 0.84 | TRPV1 (0.38) | JAK2JAK3ROCK2 | |
| SCHEMBL13983529 | 0.83 | FFAR1 (0.38) | FFAR1FFAR4IRAK4SYKNR3C1 | |
| SCHEMBL13983561 | 0.81 | FFAR1 (0.36) | FFAR1FFAR4NR3C1DHODHJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151927-A2 | 6-N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | NYCOMED GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |