Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715847 | 0.81 | PTPN1 (0.84) | NPC1RAB9APTPN1MEN1POLB | |
| SCHEMBL1542761 | 0.80 | EPHX2 (0.46) | MEN1POLBKMT2A | |
| SCHEMBL26953087 | 0.79 | PTPN1 (0.88) | NPC1RAB9APTPN1MEN1POLB | |
| SCHEMBL549076 | 0.79 | ALDH1A1 (0.54) | PTPN1TDP1 | |
| SCHEMBL1315526 | 0.79 | PTPN1 (0.87) | NPC1RAB9APTPN1MEN1POLB | |
| SCHEMBL12678698 | 0.79 | PLK1 (0.49) | HDAC2HDAC8HDAC6 | |
| SCHEMBL10294646 | 0.79 | PTPN1 (0.64) | NPC1RAB9APTPN1MEN1POLB | |
| SCHEMBL4247052 | 0.78 | NPC1 (0.86) | NPC1RAB9APTPN1MEN1KMT2A | |
| SCHEMBL14715824 | 0.77 | NPC1 (0.88) | NPC1RAB9APTPN1MEN1POLB | |
| SCHEMBL18103163 | 0.77 | NPC1 (0.88) | NPC1RAB9APTPN1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009002534-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | GILEAD COLORADO, INC. (US) | 2008-12-31 | — | — | WO | disclosed |