Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244186 | 0.87 | MAPT (0.50) | MAPTL3MBTL1RAB9AATMHPGD | |
| SCHEMBL20230373 | 0.86 | PPARG (0.68) | MAPTL3MBTL1RAB9AATMPPARG | |
| SCHEMBL20211721 | 0.86 | MAPT (0.49) | MAPTL3MBTL1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5335009 | 0.85 | LMNA (0.49) | MAPTL3MBTL1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7347287 | 0.84 | TSHR (0.47) | MAPTL3MBTL1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL765955 | 0.84 | TSHR (0.47) | MAPTL3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL1090743 | 0.83 | MAPT (0.74) | MAPTL3MBTL1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL20230316 | 0.82 | PPARG (0.49) | MAPTL3MBTL1RAB9AATMPPARG | |
| SCHEMBL13612271 | 0.81 | DGKA (0.53) | MAPTL3MBTL1SMN1; SMN2TSHRTDP1 | |
| SCHEMBL14163937 | 0.81 | DGKA (0.53) | MAPTL3MBTL1SMN1; SMN2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008155421-A2 | INDOLIN-2-ONES AND AZA-INDOLIN-2-ONES | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-24 | — | — | WO | disclosed |