Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12218598 | 0.90 | MEN1 (0.83) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL26311676 | 0.89 | MAPK1 (0.78) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL13981322 | 0.88 | MAPK1 (0.74) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL2555766 | 0.88 | MAPK1 (0.74) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL15722876 | 0.87 | KMT2A (0.74) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL7513074 | 0.86 | KMT2A (0.75) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL2956553 | 0.86 | HIF1A (0.93) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL17148022 | 0.85 | HTT (0.80) | MAPK1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL21631143 | 0.85 | HIF1A (0.74) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL21278783 | 0.85 | MAPK1 (0.70) | MAPK1SMN1; SMN2TP53HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |