Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | AHR | P35869 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985697 | 0.87 | MAPK1 (0.84) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL15722393 | 0.86 | KMT2A (0.57) | KMT2ASMN1; SMN2TP53MAPK1HPGD | |
| SCHEMBL26311676 | 0.85 | MAPK1 (0.78) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL12259253 | 0.84 | P2RY14 (0.57) | KMT2ASMN1; SMN2TP53MAPK1HPGD | |
| SCHEMBL7513074 | 0.83 | KMT2A (0.75) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL2956553 | 0.83 | HIF1A (0.93) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL15506194 | 0.82 | MAPT (0.66) | KMT2ASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL4299605 | 0.82 | HIF1A (0.74) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL21631143 | 0.82 | HIF1A (0.74) | KMT2ASMN1; SMN2TP53HIF1AEPAS1 | |
| SCHEMBL7511572 | 0.81 | MEN1 (0.88) | KMT2ASMN1; SMN2TP53MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS | 2017-08-10 | — | — | US | disclosed |
| US-9648880-B2 | Antifungal agents and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2017-05-16 | — | — | US | disclosed |
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142107-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | KMT2A 4393/4885SMN1; SMN2 4118/4885TP53 3005/4885 |
| US-20170224703-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | DPM1, ERG28, SUCLG1 | KMT2A 4393/4885SMN1; SMN2 4118/4885TP53 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.