Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | PDE5A | O76074 | 9/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986122 | 0.86 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7436271 | 0.83 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9502308 | 0.80 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7026234 | 0.79 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Cipamfylline SCHEMBL26990 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7809025 | 0.79 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7395750 | 0.78 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL13986119 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7025747 | 0.77 | ADORA1 (0.64) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7393964 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459479-B2 | Benzylated PDE4 inhibitors | BIOLIPOX AB (SE) | 2008-12-02 | — | — | US | disclosed |