Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 15/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050696 | 0.83 | TP53 (0.33) | KEAP1NFE2L2TP53MDM2 | |
| SCHEMBL5281505 | 0.83 | HRH3 (0.40) | TP53MDM2 | |
| SCHEMBL6041849 | 0.83 | TDP1 (0.33) | KEAP1NFE2L2TP53MDM2 | |
| SCHEMBL16241937 | 0.83 | TP53 (0.35) | TP53MDM2 | |
| SCHEMBL15516640 | 0.82 | TDP1 (0.48) | NFE2L2MAOB | |
| SCHEMBL2471286 | 0.79 | KDM4E (0.41) | MAOB | |
| SCHEMBL11889100 | 0.79 | LTA4H (0.46) | — | |
| SCHEMBL292142 | 0.79 | TP53 (0.32) | TP53MDM2 | |
| SCHEMBL8216043 | 0.78 | KCNA3 (0.46) | — | |
| SCHEMBL22198886 | 0.77 | MTNR1A (0.40) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |