Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.55 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848506 | 0.87 | MEN1 (0.53) | MCL1XDHALPLHPGD | |
| SCHEMBL1927068 | 0.81 | TP53 (0.58) | MCL1DHODHALPLSMN1; SMN2 | |
| SCHEMBL1925580 | 0.81 | TP53 (0.62) | DHODHALPLSMN1; SMN2 | |
| SCHEMBL11680709 | 0.80 | MCL1 (0.60) | MCL1XDHDHODHGSTP1NR4A1 | |
| SCHEMBL4851311 | 0.79 | ALPL (0.68) | ALPLALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4848211 | 0.79 | GSK3B (0.49) | ERAP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4854459 | 0.79 | ALPL (0.64) | ALPL | |
| SCHEMBL9905372 | 0.77 | XDH (0.59) | MCL1XDHGSTP1ERAP1ALDH1A1 | |
| SCHEMBL20471405 | 0.76 | DHODH (0.54) | DHODHALPLSMN1; SMN2 | |
| SCHEMBL7901147 | 0.75 | MAPT (0.69) | ALPLERAP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |