Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986931 | 0.86 | ALDH1A1 (0.52) | MEN1KMT2AMAPK1MAPK3GSK3B | |
| SCHEMBL13986933 | 0.86 | ALDH1A1 (0.52) | MEN1KMT2AMAPK1MAPK3GSK3B | |
| SCHEMBL13986977 | 0.86 | ALDH1A1 (0.52) | MEN1KMT2AMAPK1MAPK3GSK3B | |
| SCHEMBL4856612 | 0.80 | GSK3B (0.49) | MEN1KMT2AMAPK1GSK3BALDH1A1 | |
| SCHEMBL13986994 | 0.80 | MAPK1 (0.56) | KMT2AMAPK1MAPK3GSK3BALDH1A1 | |
| SCHEMBL13986978 | 0.80 | GSK3B (0.48) | GSK3BMAPT | |
| SCHEMBL13986992 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AMAPK1MAPK3GSK3B | |
| SCHEMBL13986985 | 0.78 | GSK3B (0.58) | KMT2AMAPK1GSK3BALDH1A1MAPT | |
| SCHEMBL13986956 | 0.78 | GSK3B (0.48) | KMT2AMAPK1GSK3BALDH1A1MAPT | |
| SCHEMBL13986999 | 0.77 | GSK3B (0.47) | KMT2AGSK3BALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |