Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.53 |
| ▸ | WNT1 | P04628 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987024 | 0.87 | ACHE (0.56) | — | |
| SCHEMBL5232508 | 0.84 | MAPK8 (0.55) | WNT1DYRK1AROCK2 | |
| SCHEMBL13986942 | 0.83 | GSK3B (0.48) | WNT1DYRK1AROCK2 | |
| SCHEMBL5233639 | 0.81 | GSK3B (0.52) | WNT1DYRK1AROCK2ROCK1 | |
| SCHEMBL5236116 | 0.81 | GSK3B (0.52) | DYRK1AROCK2ROCK1 | |
| SCHEMBL4848283 | 0.81 | GSK3B (0.51) | WNT1DYRK1AROCK2ROCK1 | |
| SCHEMBL13986936 | 0.80 | MAPK8 (0.51) | POLBDYRK1AROCK2 | |
| SCHEMBL4853516 | 0.79 | ALDH1A1 (0.52) | — | |
| SCHEMBL13986968 | 0.79 | MAPK8 (0.50) | DYRK1AROCK2 | |
| SCHEMBL4854577 | 0.79 | GSK3B (0.49) | WNT1DYRK1AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |