Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853151 | 0.91 | ROCK2 (0.64) | ROCK1ROCK2GSK3BNAMPTKDM5A | |
| SCHEMBL13986959 | 0.88 | MAPT (0.54) | ROCK1ROCK2GSK3BGAAMAPT | |
| Trifluoroacetic Acid SCHEMBL5658515 | 0.88 | ROCK2 (0.60) | ROCK1ROCK2GSK3BNAMPTKDM5A | |
| SCHEMBL13986981 | 0.86 | GSK3B (0.52) | ROCK1ROCK2GSK3BCNR1TRPV1 | |
| SCHEMBL13986984 | 0.85 | GSK3B (0.63) | ROCK1ROCK2GSK3BGAAMAPK1 | |
| SCHEMBL13986960 | 0.84 | GSK3B (0.53) | ROCK1ROCK2GSK3BGAAMAPK1 | |
| SCHEMBL13987003 | 0.83 | GSK3B (0.52) | GSK3BGAAMAPK1MAPTMAPK3 | |
| SCHEMBL4853063 | 0.82 | GSK3B (0.59) | ROCK1ROCK2GSK3BNAMPTFLT1 | |
| SCHEMBL13986947 | 0.81 | GSK3B (0.56) | GSK3BNAMPTGAAMAPK1MAPT | |
| SCHEMBL13986986 | 0.80 | GSK3B (0.66) | GSK3BNAMPTGAAMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |