Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | PRKX | P51817 | 2/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986962 | 0.89 | CYP1A2 (0.55) | MAPTPARP1GSK3BCYP3A4CYP2D6 | |
| SCHEMBL13986982 | 0.88 | ROCK1 (0.52) | MAPTROCK1ROCK2PARP1GSK3B | |
| SCHEMBL13986960 | 0.86 | GSK3B (0.53) | MAPTROCK1ROCK2PARP1GSK3B | |
| SCHEMBL13986984 | 0.85 | GSK3B (0.63) | MAPTROCK1ROCK2PARP1GSK3B | |
| SCHEMBL13987003 | 0.85 | GSK3B (0.52) | MAPTPARP1GSK3BGAATP53 | |
| SCHEMBL13986946 | 0.83 | MAPT (0.52) | MAPTGSK3BGAATP53 | |
| SCHEMBL13986947 | 0.83 | GSK3B (0.56) | MAPTPARP1GSK3BGAATP53 | |
| SCHEMBL13986981 | 0.83 | GSK3B (0.52) | MAPTROCK1ROCK2PARP1GSK3B | |
| SCHEMBL13986958 | 0.82 | LMNA (0.62) | MAPTROCK1ROCK2PARP1GSK3B | |
| SCHEMBL13986950 | 0.81 | GSK3B (0.59) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |