Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 7/20 | 0.56 |
| ▸ | TACR2 | P21452 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.46 |
| ▸ | NEK4 | P51957 | 3/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986996 | 0.90 | ROCK1 (0.60) | TACR3ROCK1ROCK2GSK3BMAPK1 | |
| SCHEMBL14348311 | 0.88 | ROCK1 (0.53) | ROCK1ROCK2GSK3BMAPK1MAPK3 | |
| SCHEMBL13986994 | 0.86 | MAPK1 (0.56) | TACR3ROCK1ROCK2GSK3BKDM4E | |
| SCHEMBL13986995 | 0.77 | PDE2A (0.49) | TACR3ROCK1ROCK2GSK3BALDH1A1 | |
| SCHEMBL4853003 | 0.77 | GSK3B (0.65) | TACR3ROCK1ROCK2GSK3BKDM4E | |
| SCHEMBL20181396 | 0.77 | ROCK1 (0.78) | TACR3ROCK1ROCK2GSK3BMAPK1 | |
| SCHEMBL20181642 | 0.77 | ROCK1 (0.78) | TACR3ROCK1ROCK2GSK3BMAPK1 | |
| SCHEMBL1750449 | 0.76 | GSK3B (0.61) | ROCK1GSK3BKDM4EALDH1A1LMNA | |
| SCHEMBL4851367 | 0.76 | GSK3B (0.61) | GSK3BKDM4ELMNAMAPK1GSK3A | |
| SCHEMBL13986992 | 0.76 | ALDH1A1 (0.50) | TACR3ROCK1ROCK2GSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |