Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856612 | 0.89 | GSK3B (0.49) | GSK3BALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL13987016 | 0.88 | MAPT (0.47) | GSK3BALDH1A1KDM4EMAPTCYP2C9 | |
| SCHEMBL13987019 | 0.83 | GSK3B (0.50) | GSK3BHDAC1CYP2C9GSK3ADYRK1A | |
| SCHEMBL1750449 | 0.77 | GSK3B (0.61) | GSK3BHDAC1ALDH1A1KDM4ENPC1 | |
| SCHEMBL2944943 | 0.77 | HDAC1 (0.47) | GSK3BHDAC1GSK3ADYRK1AHDAC3 | |
| SCHEMBL4847269 | 0.76 | GSK3B (0.81) | GSK3BCYP2C9TSHRMAPK1CASP1 | |
| SCHEMBL4856682 | 0.76 | GSK3B (0.69) | GSK3BMAPTCYP2C9HPGDTSHR | |
| SCHEMBL4856266 | 0.75 | CASP1 (0.69) | GSK3BCYP2C9TSHRMAPK1CASP1 | |
| SCHEMBL14375208 | 0.75 | GSK3B (0.47) | GSK3BHDAC1GSK3ADYRK1ACASP1 | |
| SCHEMBL4851138 | 0.74 | GSK3B (0.58) | GSK3BHDAC1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |