Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987016 | 0.85 | MAPT (0.47) | GSK3BCASP1GSK3ADYRK1A | |
| SCHEMBL11246270 | 0.78 | CASP1 (0.54) | GSK3BCDC7CASP1GSK3ADYRK1A | |
| SCHEMBL1750449 | 0.77 | GSK3B (0.61) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13987019 | 0.76 | GSK3B (0.50) | GSK3BITKHDAC3HDAC4HDAC1 | |
| SCHEMBL13987014 | 0.75 | GSK3B (0.50) | GSK3BCASP1HDAC3HDAC4HDAC1 | |
| SCHEMBL4856612 | 0.75 | GSK3B (0.49) | GSK3BCASP1 | |
| SCHEMBL4856466 | 0.73 | GSK3B (0.64) | GSK3BCDC7ROCK2MAP4K4CLK4 | |
| SCHEMBL4856282 | 0.72 | GSK3B (0.69) | GSK3BCDC7ROCK2MAP4K4CLK4 | |
| SCHEMBL13986963 | 0.72 | GSK3B (0.56) | GSK3BHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14374752 | 0.71 | SNCA (0.49) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |