Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 7/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669391 | 0.92 | GABRG2 (0.44) | GABRG2GABRB3GABRA2PIK3CANPY1R | |
| SCHEMBL2661686 | 0.91 | GABRG2 (0.53) | GABRG2GABRB3GABRA2MAPTPIK3CA | |
| SCHEMBL2669390 | 0.89 | GABRG2 (0.40) | GABRG2GABRB3GABRA2HPGDPIK3CA | |
| SCHEMBL4916018 | 0.89 | GABRG2 (0.43) | GABRG2GABRB3GABRA2NPY1RNPY5R | |
| SCHEMBL2661842 | 0.88 | GABRG2 (0.42) | GABRG2GABRB3GABRA2PIK3CANPY1R | |
| SCHEMBL2655799 | 0.88 | GABRG2 (0.52) | GABRG2GABRB3GABRA2SMN1; SMN2NPY1R | |
| SCHEMBL2660625 | 0.87 | GABRG2 (0.39) | GABRG2GABRB3GABRA2PIK3CANPY1R | |
| SCHEMBL2656669 | 0.87 | GABRG2 (0.41) | GABRG2GABRB3GABRA2CNR1SMN1; SMN2 | |
| SCHEMBL2659925 | 0.86 | GABRG2 (0.46) | GABRG2GABRB3GABRA2MAPTNPY1R | |
| SCHEMBL2661662 | 0.86 | CNR1 (0.39) | GABRG2GABRB3GABRA2CNR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | GABRG2 592/4885GABRB3 332/4885GABRA2 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.