Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.52 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.47 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998618 | 0.93 | GSK3B (0.54) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL13998622 | 0.91 | GSK3B (0.48) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL13885055 | 0.89 | GSK3B (0.51) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL12953929 | 0.86 | GSK3B (0.71) | GSK3BCDK2 | |
| SCHEMBL12954092 | 0.85 | GSK3B (0.49) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL13998621 | 0.84 | GSK3B (0.52) | GRIN2BCYP2D6CYP2C9GSK3BCYP3A4 | |
| SCHEMBL11931136 | 0.84 | GSK3B (0.51) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL12953546 | 0.84 | TRPC3 (0.53) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL13993128 | 0.84 | TRPC3 (0.49) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 | |
| SCHEMBL12953650 | 0.83 | GSK3B (0.54) | GRIN2BCYP2D6CYP2C9GSK3BTRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |