Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.43 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | TGM2 | P21980 | 3/20 | 0.39 |
| ▸ | TGM1 | P22735 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | F13A1 | P00488 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547159 | 0.92 | GSK3B (0.40) | TRPC3TRPC7GSK3BTGM2TGM1 | |
| SCHEMBL13993128 | 0.82 | TRPC3 (0.49) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL12954092 | 0.81 | GSK3B (0.49) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL13998619 | 0.80 | GRIN2B (0.52) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL14547315 | 0.79 | GSK3B (0.48) | GSK3B | |
| SCHEMBL11931136 | 0.79 | GSK3B (0.51) | TRPC3TRPC7GSK3BGRIN2BCYP2D6 | |
| SCHEMBL12953546 | 0.79 | TRPC3 (0.53) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL13998618 | 0.78 | GSK3B (0.54) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL12953650 | 0.78 | GSK3B (0.54) | TRPC3TRPC7GSK3BGRIN2BSMN1; SMN2 | |
| SCHEMBL12953929 | 0.78 | GSK3B (0.71) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |