Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10122263 | 0.89 | HTT (0.49) | HTTSMN1; SMN2PKMUSP2MLYCD | |
| SCHEMBL823974 | 0.81 | HTT (0.55) | HTTSMN1; SMN2PKMUSP2CTSS | |
| SCHEMBL13993504 | 0.76 | GAA (0.45) | HTTSMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL10123383 | 0.75 | GAA (0.44) | HTTSMN1; SMN2CYP2C19ALDH1A1GAA | |
| SCHEMBL10123579 | 0.75 | GAA (0.44) | HTTSMN1; SMN2CYP2C19ALDH1A1GAA | |
| SCHEMBL11032606 | 0.74 | HTT (0.51) | HTTSMN1; SMN2PKMUSP2CTSS | |
| SCHEMBL8909399 | 0.72 | HTT (0.50) | HTTSMN1; SMN2PKMUSP2CTSS | |
| SCHEMBL10122411 | 0.72 | GAA (0.47) | HTTSMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL27672077 | 0.71 | HTT (0.49) | HTTSMN1; SMN2PKMMLYCDCTSS | |
| SCHEMBL10123504 | 0.71 | LMNA (0.45) | SMN1; SMN2CYP2C9CYP2C19ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147474-A2 | SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES | SIGA TECHNOLOGIES, INC. (US) | 2008-12-04 | — | — | WO | disclosed |