Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032606 | 0.81 | HTT (0.51) | HTTSMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL823974 | 0.78 | HTT (0.55) | HTTSMN1; SMN2PKMCTSSCYP2C9 | |
| SCHEMBL14152692 | 0.77 | MEN1 (0.46) | HTTSMN1; SMN2MEN1KMT2ACTSS | |
| SCHEMBL13993304 | 0.72 | HTT (0.49) | HTTSMN1; SMN2PKMCTSSCYP2C9 | |
| SCHEMBL10122263 | 0.72 | HTT (0.49) | HTTSMN1; SMN2PKMCTSSCYP2C9 | |
| SCHEMBL4707114 | 0.70 | HTT (0.65) | HTTSMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL6444661 | 0.69 | HTT (0.63) | HTTSMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL27672077 | 0.69 | HTT (0.49) | HTTSMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL27062451 | 0.69 | HTT (0.54) | HTTSMN1; SMN2PKMMEN1KMT2A | |
| SCHEMBL14226183 | 0.69 | CTSL (0.54) | HTTSMN1; SMN2MEN1KMT2ACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |